BGC > Product Search > Palbociclib hydrochloride | 827022-32-2

Molecular Formula: C24H30ClN7O2
Molecular Weight: 483.9937
HS Code: 29399990

Molecular Formula: C24H30ClN7O2
Molecular Weight: 483.9937
HS Code: 29399990

Molecular Formula: C24H30ClN7O2
Molecular Weight: 483.9937
HS Code: 29399990

Molecular Formula: C24H30ClN7O2
Molecular Weight: 483.9937
HS Code: 29399990

Molecular Formula: C24H30ClN7O2
Molecular Weight: 483.9937
HS Code: 29399990

Description :
Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50=0.011 μmol/L) and Cdk6 (IC50=0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.

• Molecular Weight :483.99
• Purity :> 98%

Molecular Formula :
C24H29N7O2.HCl
Canonical SMILES :
CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
InChI :
InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H
InChIKey :
STEQOHNDWONVIF-UHFFFAOYSA-N
Appearance :
Yellow solid powder
Synonyms :
PD 0332991; PD 332991; PD0332991; PD-0332991; Palbociclib hydrochloride

More details are to be found here

Purity : 98%
Smile code : O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.[H]Cl
MDL Number : MFCD22420809
MolFormula : C24H30ClN7O2
MolWeight : 483.9937
Available in stock : 12.446

More details are to be found here

Smile code:
O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.[H]Cl
MDL Number:
MFCD22420809
Purity :
98%
Available in stock:
20.226 g

More details are to be found here

Smile code:
O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.[H]Cl
MDL Number:
MFCD22420809
Purity :
98%
Available in stock:
20.226 g

More details are to be found here

Smile code:
O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.[H]Cl
MDL Number:
MFCD22420809
Purity :
98%
Available in stock:
20.226 g

More details are to be found here